Radiotherapy FCPS new syllabus (Radio Biology)

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Radiotherapy FCPS new syllabus (Radio Biology)

This entry is part 5 of 7 in the series Radiotherapy FCPS syllabus

Radio Biology (50 marks, 25 questions)

1. General Principles of Radiobiology:

Describes cellular systems (hierarchical, flexible) and

their response to radiation, Contrasts parallel and serial systems, Outlines the principles of cell survival curves, regrowth curves, clonogenic assay, Describes the relevance of Linear Energy Transfer (LET) to cellular damage. Describes radiation damage at the cellular level (including outcome phenotypes, chromosome damage and cell radio sensitivity), Compares bystander with direct effects of radiation, Compares the effects of low and high dose rate radiation and Describes interactions between systemic anti-cancer therapies and radiotherapy.

2. Molecular Biology of Radiation Damage and Repair: Describes the basics of experimental molecular radiobiology, including sensitizers, Explains the molecular processes involved in radiation damage, Explains the molecular processes involved in radiation damage repair, Discusses interaction between radiation and other agents and Describes laboratory experimental DNA damage and repair.

3. Normal Tissue Radiobiology: Describes radiation damage at the cellular level, including outcome phenotypes, chromosome damage and cell radio sensitivity, Defines cellular systems (hierarchical and flexible) and describes their response to radiation, Describes normal tissue damage (early and late). Discusses the concept of normal tissue tolerance, Discusses the factors influencing tolerance, Describes the effects of radiation on different tissues and organs including unplanned whole body exposure and Discusses Equivalent Uniform Dose (EUD), Discusses the genetic factors and co-morbidities, including auto-immune factors, which influence tolerance, Lists the tolerance levels for different tissues and organs, Discusses organ tolerance to retreatment with radiation, Describes the schemes for reporting normal tissue damage.

4. Radiobiology: Discuss population radiobiology, Explains the production of the cell survival curve. Describes descriptive models, e.g. linear quadratic model, Discusses the concept of damage (lethal, sub-lethal, potentially lethal). Discusses the concept of repair (early and late). Describes the effect of cell cycle on radiation sensitivity, Discusses repopulation, Explains the role of the cell survival curve as a basis for fractionation, Defines terms describing cellular sensitivity (SF2, a, ẞ, mean inactivation dose), Discusses the a/ẞ ratio and its relevance to acute and late responding tissues, Describes iso-effect curves (various forms) and formulae, including BED, Discusses fractionation and its influence on outcome with varying a/B ratio, Defines hyperfractionation, accelerated fractionation and hypofractionation and Discusses the influence of gaps in radiotherapy and their management, Discusses radiation protectors, Describes low dose hyper-radio sensitivity and Describes effects of total body irradiation.

5. Interaction Between Radiation and Other Agents: Discusses the interaction between radiation and other agents, Discusses the interaction with chemotherapy (before, during or following radiation) and Describes the basic principles of the interaction with hyperthermia.

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