Radiotherapy FCPS new syllabus (Clinical Pharmacology)

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Radiotherapy FCPS new syllabus (Clinical Pharmacology)

This entry is part 3 of 7 in the series Radiotherapy FCPS syllabus

Clinical Pharmacology (40 marks, 20 Questions)


1. Mode of action of cytotoxic drugs

Mechanisms of action for each drug. Discuss the mechanisms of drug resistance, drug resistance modifiers, strategies to optimize efficacy of cytotoxic drugs

2. Drug Design and Development

Describes novel therapeutic targets

Outlines the process of new drug discovery and development

Outlines the principles of preclinical assessment of candidate compounds Discusses the role and design of clinical studies (Phase I, II, III, IV)

3. Pharmacokinetics and Pharmacodynamics

Discusses the general principles of pharmacokinetics and interprets pharmacokinetic data Explains the role of the route and timing of administration, Discusses the importance of plasma concentration and its relationship to drug actions, Defines AUC and discusses its importance, Discusses drug activation, metabolism and clearance, Discusses the importance of protein and tissue binding and Describes the importance of drug concentration at target site.

4. Clinical Use of Systemic Therapies

Describes dose response curves, Explains the concept of dose intensity. Discusses the effects of single agent and combination therapy. Explains the role of adjuvant and neo-adjuvant therapy. Describes the principles of regional therapy. Discusses targeting of drugs Outlines modification of drug resistance. Describes the clinical pharmacology and technology of continuous infusion. Describes the clinical pharmacology of intrathecal treatment.

5. Toxicity of Chemotherapy

Describes the dose limiting and common toxicities. Describes dose-related and idiosyncratic toxicity. Defines the concepts of acute and long term toxicity. Discusses the mechanisms of toxicity. Discusses chemical and other factors modifying drug toxicity. Describes safe handling of cytotoxic drugs. Describes strategies to optimise efficacy of cytotoxic therapy.

6. Clinical Pharmacology of Analgesics

Outlines the clinical pharmacology of morphine and derivatives, Discusses the use of drug combinations for pain management. Describes different formulations, e.g. slow release and patch formulations. Describes different formulations and their use

7. Clinical Pharmacology of Steroids and Anti-emetics

Discusses the use of steroids with chemotherapy Lists the classes of antiemetic and discusses their use

8. Drug Interactions in Cancer Treatment

Discusses common or important interactions between drugs used in cancer therapy and other commonly used agents

9. Endocrine Therapy

Describes their mechanisms of action, Describes the mechanism of resistance, Lists the common side-effects and discusses the effect of combination with other therapies

10. Biological and Novel Therapies

Discusses biological therapies, their mechanism of action and their combination with standard therapy

Discusses the mode of action of interferon, interleukins, growth factors, antibody therapy, small molecule inhibitors of signaling pathways, gene therapy and immunotherapy, Describes novel targets for anti-cancer drugs, including vasculature, cell signal control and oncogene products, Outlines mode of action of bio-reductive drugs and Outlines mode of action of cancer vaccines

11. High Dose Therapy

Explains the clinical pharmacology and rationale of high-dose therapy, Describes methods for protection/rescue of stem cells, Lists unusual toxicities due to high dose therapy.

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